Dr. Joseph Sarhan
Joseph Sarhan MD, PhD
Education:
MD, PhD Tufts University School of Medicine, Boston MA (2011-2020)
BS The College of New Jersey, Ewing NJ (2005- 2010)
Career/Academic Appointment:
Residency – chief of cosmetics, PGY4, Dermatology, Yale-New Haven Hospital, New Haven, CT (2021-2024)
Professional Honors & Recognition:
2023: Chief of Resident Cosmetics at Yale Dermatology, New Haven CT
2021: 1st Place MIT hackathon: “Africa Takes on COVID-19” –pooled COVID PCR testing
2020: Cum Laude, Tufts University, School of Medicine, Boston MA
2015: Charlton Lecture 1st Place Graduate Student Presenter, Boston MA
2009: Phi Betta Kappa, The College of New Jersey, Ewing NJ
Peer Reviewed Journal Articles
Peer Reviewed Journal Articles
- Joseph Sarhan, Beiyun C Liu, Hayley I Muendlein, Peng Li, Rachael Nilson, Amy Y Tang, Anthony Rongvaux, Stephen C Bunnell, Feng Shao, Douglas R Green, Alexander Poltorak. Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection. Proceedings of the National Academy of Sciences. 2018. https://doi.org/10.1073/pnas.1809548115
- Joseph Sarhan, Beiyun C Liu, Hayley I Muendlein, Chi G Weindel, Irina Smirnova, Amy Y Tang, Vladimir Ilyukha, Maxim Sorokin, Anton Buzdin, Katherine A Fitzgerald, Alexander Poltorak. Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis. Cell Death & Differentiation. 2018.
https://doi.org/10.1038/s41418-018-0122-7
- Joseph Sarhan* (co-first author), Hayley I Muendlein*, Beiyun C Liu, Wilson M Connolly, Stephen A Schworer, Irina Smirnova, Amy Y Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak. Constitutive interferon attenuates RIPK1/3-mediated cytokine translation. Cell Reports. 2020.
https://doi.org/10.1016/j.celrep.2019.12.073
- Beiyun C Liu, Joseph Sarhan, Alexander Panda, Hayley I Muendlein, Vladimir Ilyukha, Jörn Coers, Masahiro Yamamoto, Ralph R Isberg, Alexander Poltorak. Constitutive interferon maintains GBP expression required for release of bacterial components upstream of pyroptosis and anti-DNA responses. Cell reports. 2018.
- Beiyun C Liu, Joseph Sarhan, Alexander Poltorak. Host-intrinsic interferon status in infection and immunity. Trends in molecular medicine. 2018.
- Gautham K Rao, Albert Wong, Mark Collinge, Joseph Sarhan, Timur O Yarovinsky, Vinod S Ramgolam, Matthias Gaestel, Ruggero Pardi, Jeffrey R Bender. T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K. PLoS One. 2018.
- Selinda J Orr, Ashley R Burg, Tim Chan, Laura Quigley, Gareth W Jones, Jill W Ford, Deborah Hodge, Catherine Razzook, Joseph Sarhan, Yava L Jones, Gillian C Whittaker, Kimberly C Boelte, Lyudmila Lyakh, Marco Cardone, Geraldine M O’Connor, Cuiyan Tan, Hongchuan Li, Stephen K Anderson, Simon A Jones, Weiguo Zhang, Philip R Taylor, Giorgio Trinchieri, Daniel W McVicar. LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells. PLoS Pathogens. 2013.
Case Reports/ Other
- Simon F Roy, Joseph Sarhan, Xinran Liu, Michael J Murphy, Christopher G Bunick, Keith A Choate, William B Damsky, Jennifer M McNiff. Inguinal patch in mpox (monkeypox) virus infection and eccrine syringometaplasia: report of two cases with in situ hybridization and electron microscopy findings. Br J Dermatol. 2023
- Joseph Sarhan, Anar Mikailov. Comment on: “Developing an international standard for the classification of surface anatomic location for use in clinical practice and epidemiologic research”. Journal of the American Academy of Dermatology. 2020.